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For example, chondrocytes isolated from OA cartilage displayed significant senescence levels, and ABT263 treatment reduced the expression of inflammatory cytokines and promoted cartilage matrix aggregation in OA chondrocytes ( Next, we tested the potential of FOXO4-DRI in removing senescent chondrocytes, which has not been reported before

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We used an earlier collected prescription database of the hospital pharmacy from patients clinically admitted in our tertiary referral centre, the Academic Medical Center, Amsterdam, the Netherlands (AMC) and linked these data to the clinical laboratory data on serum pH, electrolytes (Na + , Cl − , HCO 3 − ), albumin and 5-oxoproline measurements